That's an interesting concept! Would obviously clash a bit with the Companion bonding, but I'm totally down with the Companions not always being just Doctor Sidekicks, especially more independent ones like Leela.
The top 5 most expensive quads affected would be Fire Demons, Triplicate Girl, Arthrian Invaders, Blood Demons, and Foot Clan Ninja. An odd lot, for sure, but I'd have fun having Leela lead a bunch of demons and ninjas into battle.