Criminal Frame-Up allows Kingpin to change one Crime Fighter, Lawman, or Vigilante Hero into a Criminal for the current game. This can be used to either enable synergy for yourself (or potentially a teammate) or on occasion disrupt your opponent's synergy. As the disruption option is not guaranteed to be relevant in non-drafting formats, it's typically best to have at least one frame-up option among your own forces if you wish to get any value out of this power.

Current Synergies Kingpin can enable:

Kingpin's own Kingpin of Crime, allowing him to grant the newly minted Criminal an extra defense die and potentially and extra point of movement and attack die as well. This is the most efficient synergy to shoot for, as it does not require a third card for Kingpin to 'Middleman' for.

Amanda Waller's Suicide Squad (and by extension, her other powers), granting the new Criminal 'bonding' with other Suicide Squad members, an extra attack die under certain situations, and the negative of potentially turning on you. None of Waller's positive powers can come into play at the same time as Kingpin of Crime. Note that Waller also offers Thief synergy as Kingpin does.

Black Mask's Criminal Motivation, granting an extra attack die at the risk of receiving a wound. Criminal Motivation does not require Order Markers on Black Mask to be effective, and thus does not interfere with Kingpin of Crime, though you would need to use the Street Thugs or the like to get Black Mask into position without disrupting Kingpin of Crime.

Hush's Obsessive Vendetta, granting an extra attack die against a select target. Like Waller, Hush's benefits cannot come into play at the same time as Kingpin of Crime, though Kingpin himself can benefit from Obsessive Vendetta.

Kingpin I's Organised Crime, granting bonding. As you can not draft both Fisks into the same army, this can only come into play if you have a Hero capable of copying an enemy Kingpin I's powers or your opponent takes control of your Frame-Up target.

Lex Corp Security's Criminal Alliance, granting bonding and an extra attack die. Cannot come into play at the same time as Kingpin of Crime.

Lex Luthor I's Criminal Deception and Villainous Entrapment, granting protection to Lex and bonuses to leaving engagement attacks. Neither of these powers interfere with Kingpin of Crime or require much positioning on Lex's part.

Redmist's Payoff, granting bonding. Cannot come into play at the same time as Kingpin of Crime, but can be used against an enemy Hero Kingpin has framed.

The Riddler's Criminal Ambush, granting a conditional extra attack die. Does not interfere with Kingpin of Crime, but moving Riddler into position will without outside help.

The Hood's Criminal Ambition, granting conditional bonding. Cannot be used at the same time as Kingpin of Crime, but can be used on Kingpin himself.

Ventriloquist's Heist Planner, granting extra move. Does not interfere with Kingpin of Crime, but Ventriloquist will need help to move into position without doing so. Heist Planner can also boost Thieves as Kingpin of Crime can.

Wizard's Criminal Leadership, granting extra move. Uniquely, at present, Wizard is a Criminal with Criminal synergies and thus can be activated without risk of disrupting Kingpin of Crime, though he does not require any positioning or Order Markers for Criminal Leadership to come into play in the first place. Unfortunately, Wizard's Force Field X does not play especially well with Kingpin of Crime.

Madame Hydra's Necessary Sacrifices, allowing Ophelia to redirect wounds onto the framed Hero. Does not interfere with Kingpin of Crime, though it isn't a very useful power unless Ophelia is doing something to earn the save, which most likely will disrupt Kingpin of Crime without outside help.

In addition to the synergies he can enable, Kingpin can break the synergies granted by a number of figures; most prominently Luke Cage and the various Robins.

Daredevil, Judge Dredd, Lieutenant Stone, Rorschach, and Spoiler all have anti-Criminal powers that Kingpin can enable against an enemy figure. Of those, all but Dredd and Spoiler are valid Frame-Up targets themselves, allowing them to pull double duty where one of them can either be framed if no better targets are present, or get a bonus against a framed enemy.